解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUNDS:The combination gemcitabine-oxaliplatin (GEMOX) is frequently used in patients with advanced biliary tract carcinoma (BTC). However, this is only based on phase II studies performed in selected patients.We assessed the efficacy and safety of the GEMOX regimen in non-selected patients with advanced BTC. MET...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000316848
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:This study was conducted to determine the antimicrobial susceptibility patterns among common pathogens in the intensive care unit (ICU) of a university hospital in Iran between 2006 and 2009. METHODS:The isolates cultured in appropriate media and antimicrobial susceptibility were determined by disk diffusio...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000321032
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the value of tumor markers in monitoring chemotherapy response and predicting prognosis in patients with advanced non-small cell lung cancer (NSCLC). METHODS:We studied carcinoembryonic antigen (CEA), CYFRA21-1 and neuron-specific enolase (NSE) of 111 untreated patients wi...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000317580
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:In this study, the in vitro antimicrobial activity and spectrum of new dimeric compounds derived from the cyanobacterial alkaloid nostocarboline were investigated. The mechanism of action and selectivity to bacteria were studied and compared to the cationic antiseptic chlorhexidine. METHODS:Minimal inhibito...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000320033
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Bacterial endotoxin is known to act as a potent trigger of disseminated coagulation and septic shock. During clinical antibiotic treatment, endotoxin may be released from Gram-negative bacteria. It is known that antibiotic classes differ in their ability to induce endotoxin release. AIM:It was the aim of th...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000321622
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Ginkgolic acids (GAs), extracted from the seed coat of Ginkgo biloba L. Our previous study has shown that GA monomer could inhibit the growth of Hep-2 significantly and induce the fragmentation of the chromosomal DNA. To further assess the antitumor potential and turn it into a candidate new antitumor drug, ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000317750
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND/AIMS:A single-institution phase I trial to determine the feasibility of using filgrastim or pegfilgrastim to increase the dose intensity of biweekly docetaxel and gemcitabine. METHODS:Patients with metastatic solid tumors received gemcitabine 3,000 mg/m(2) and increasing doses of docetaxel (55 mg/m(2) in 10...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000313526
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Cisplatin resistance has been mainly associated with decreased cellular accumulation and increased intracellular glutathione (GSH) levels. ATP is known to increase the membrane permeability of cells and to decrease intracellular GSH levels. Our study aimed at using extracellular ATP to sensitize ovarian carc...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000287351
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Some new quinolones (NQs) modulate polymorphonuclear leukocyte (PMN) functions. We investigated these effects on PMN functions at concentrations <10 microg/ml. METHODS:Chemotactic activity and the production of reactive oxygen species (ROS) were measured using a 48-well chemotaxis chamber and by luminol-dep...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000232451
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:5-Fluorouracil (5-FU) is a widely used drug in head and neck squamous cell carcinoma (HNSCC). Thymidylate synthase (TS), which is the target enzyme of 5-FU, has been demonstrated to be a key regulatory enzyme. In this study, we examined whether TS expression is correlated with chemosensitivity to 5-FU, cell ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000175465
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The aim of this clinical study was to evaluate the efficacy of combination chemotherapy of oxaliplatin, leucovorin and continuous-infusion 5-fluorouracil (5-FU) for advanced gastric cancer. METHODS:Patients with previously untreated gastric cancer with measurable disease received oxaliplatin (100 mg/m(2), d...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000219434
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Levofloxacin and tobramycin, alone and in combination with cefepime, were investigated for their in vitro activities and post-antibiotic effects (PAEs) on Pseudomonas aeruginosa. METHODS:The in vitro activities of tobramycin and levofloxacin in combination with cefepime were determined by microbroth chequer...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000265128
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Ciprofloxacin is commonly used and considered to be relatively safe in patients with cirrhosis, especially in the treatment of enteric and urinary tract infections. Among the adverse effects of ciprofloxacin, neurologic complications are rare. METHODS/RESULTS:We report a case of hemiballism and altered ment...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000218098
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:An ethylacetate-soluble fraction (ET4) from the lichen Ramalina farinacea has previously been shown to inhibit the infectivity of lentiviral and adenoviral vectors, as well as wild-type HIV-1. We now determined the antiviral activity of ET4 against other wild-type viruses, including the herpes simplex virus ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000194974
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:In this study (part of the global TEST program), the in vitro activity of tigecycline, a member of a new class of antimicrobial agents, the glycylcyclines, against clinical isolates collected in Italy was evaluated. METHODS:A total of 200 clinical isolates were collected and identified in our institution du...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000112415
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Very little is documented in the medical literature on the association between malaria parasitemia and febrile neutropenia in patients undergoing cancer chemotherapy. METHODS:This report will concentrate on the clinical presentation and outcome of 3 patients with haematological malignancies undergoing chemo...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000118663
更新日期:2008-01-01 00:00:00
abstract::Local chemotherapy is an option in bone metastasis treatment. On the other hand, evaluation of side effects on bone is a difficult issue in drug development and biomaterials research. Most animal models to date are inappropriate or not feasible. Rabbits are an alternative to other bigger mammals and have an appropriat...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000153315
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The combination of 5-fluorouracil (5-FU), cisplatin and interferon (IFN)-alpha was found to result in a high response rate in advanced esophageal squamous cell carcinoma (SCC). METHODS:Resectable cases of esophageal SCC were treated with 3 cycles of chemotherapy consisting of cisplatin 70 mg/m(2) i.v. on da...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000151353
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Nevirapine (NVP) is a nonnucleoside reverse transcriptase inhibitor used in HIV patients and recently evaluated as a differentiating and antiproliferative agent in human malignancies. However, while NVP is a safe treatment in immunocompromised patients, NVP-containing regimens have been associated with sever...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章
doi:10.1159/000159273
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine the therapeutic adult antibiotics prescribed by dental practitioners working in the Jordan University Hospital. METHODS:Adult dental prescriptions for therapeutic antibiotics issued between 1 January 2003 and 31 May 2004 by dental specialists working in the Jordan Unive...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000112313
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Gallbladder cancer is a common and lethal digestive malignancy which is nonsensitive to routine chemotherapy. Doxorubicin (DOX) is one of the major chemotherapeutic drugs for patients with gallbladder cancer. We tried to evaluate if combined use of somatostatin (SST) and DOX could have synergistic effect in ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000158662
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Fungal infections are common and life threatening among immunosupressive patients. Rare side effects may occur related to the use of voriconazole, which is the drug of choice in invasive aspergillosis. PATIENTS AND METHODS:Neuropathy was determined through clinical and electromyographic findings during the ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000140466
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The collagen gel droplet embedded drug sensitivity test (CD-DST) is a new anticancer drug sensitivity test that only requires a small number of cells. We report the use of this test in the choice of adjuvant chemotherapy for treatment of a rare case of ovarian cancer involving malignant transformation of ova...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000099985
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Ceftazidime is a third-generation cephalosporin almost entirely eliminated by glomerular filtration and dose reductions are essential in patients with renal impairment. The physicochemical and pharmacokinetic properties of ceftazidime make it susceptible to be eliminated by continuous renal replacement thera...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章
doi:10.1159/000100864
更新日期:2007-01-01 00:00:00
abstract::In this study, rational dosing guidelines for amphotericin B-deoxycholate (AmB) are proposed for children. AmB steady-state trough concentrations (C(ss,trough)) and plasma creatinine concentrations (C(creat)) were measured in 83 children (age: 10 months to 18 years) receiving prophylactic AmB therapy (1 mg/kg/day). Ma...
journal_title:Chemotherapy
pub_type: 临床试验,杂志文章
doi:10.1159/000100013
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Recurrent tumor growth of colorectal carcinoma at the peritoneal site remains an unsolved problem. The aim of this study was to investigate whether the substance taxol (paclitaxel) can alter intraperitoneal tumor spread using different modes of drug application. METHODS:Intraperitoneal tumor growth was indu...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000110005
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Chronic hepatitis B (CHB) affects 400 million people worldwide and is a major cause of morbidity and mortality. It is known that HBV DNA sequences were detected after the clearance of serum hepatitis B surface antigen (HBsAg) often in serum, liver and peripheral blood mononuclear cells. The objectives of our...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000109770
更新日期:2007-01-01 00:00:00
abstract::Combination antiretroviral (ARV) treatment is a potent and effective therapy for human immunodeficiency virus infection. Unfortunately, ARV drugs frequently interact among themselves, as well as with other anti-infectives. These interactions determine positive or negative consequences resulting in recommendations to a...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000098247
更新日期:2007-01-01 00:00:00
abstract::Pyrazinamide (PZA) is an unconventional frontline tuberculosis drug characterized by high in vivo sterilizing activity, but poor in vitro activity. The study on the mechanism of action of PZA has attracted significant attention because of the peculiarity of PZA and its ability to shorten the tuberculosis chemotherapy....
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000107723
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:Pneumolysin is an important virulence factor of Streptococcus pneumoniae with cytotoxic and proinflammatory activities released during growth and autolysis. At concentrations above the minimal inhibitory concentration, the protein-synthesis-inhibiting antibiotics erythromycin, clindamycin and rifampicin inhib...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000107691
更新日期:2007-01-01 00:00:00
abstract::Our previous study demonstrated that the effects of isoniazid (INH) on Mycobacterium tuberculosis at the cellular level varied according to the growth phases. In this study, the variations in the INH action on M. avium strain NCTC 8559 are reported. M. avium cells grown on Middlebrook 7H10 agar were harvested at diffe...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000104470
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Because of the dramatic situation of malaria in Africa, there is an urgent need to find new and cheap drugs, such as herbal medicines. Here we report the study of the in vitro and in vivo antimalarial activity of Momordica balsamina alone or in a traditional mixture used in Niger. METHODS:Extracts were obta...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000095960
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:This study was designed to examine the efficacy and compliance of S-1 for the patients with peritoneal metastasis of gastric cancer. METHODS:Sixteen consecutive patients with peritoneal metastasis of gastric cancer were treated with S-1. Their survival was compared with that of the historical control group ...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000096002
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Myelodysplastic syndrome (MDS) is an iron overload condition. Copper deficiency itself might induce dysplastic changes and iron overload. The relationship between the iron and copper metabolism is analyzed in MDS patients. METHODS:Copper, iron and ceruloplasmin levels were established, and transferrin satur...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000091307
更新日期:2006-01-01 00:00:00
abstract::The introduction of highly active antiretroviral therapy (HAART) has significantly modified the course of human immunodeficiency virus (HIV) disease, with longer survival and improved quality of life of HIV-infected subjects. However, HAART regimens, especially those including protease inhibitors, have been shown to c...
journal_title:Chemotherapy
pub_type: 杂志文章,评审
doi:10.1159/000093034
更新日期:2006-01-01 00:00:00
abstract::Chronic bone and soft tissue suppurations have become more frequent recently due to the increasing number of high-energy injuries. There are certain antibiotic beads available for local administration, but they cannot always be applied specifically against the pyogenic microorganisms. In the present study, a new techn...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000092371
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:We investigated the presence of Helicobacter pylori in laryngeal cancer specimens to reveal whether or not this is a risk factor in the development of squamous cell carcinoma of the larynx. METHODS:Sixty-nine total laryngectomy specimens with the pathologic diagnosis of squamous cell carcinoma and 30 larynge...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000091727
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:To identify parameters/factors that may contribute to the differential sensitivity to etoposide in two clones isolated from the human ovarian carcinoma SKOV-3 cell line, which does not express p53 and is resistant to platinum-based regimens. METHODS:Differential sensitivity of the cells to etoposide was mon...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000093009
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Considering the potentials of gatifloxacin and moxifloxacin in the treatment of tuberculosis, the present study was aimed to define resistance to both these drugs. METHODS:Fifty Mycobacterium tuberculosis isolates, consisting of 30 ofloxacin-susceptible and 20 ofloxacin-resistant strains, were tested for th...
journal_title:Chemotherapy
pub_type: 杂志文章
doi:10.1159/000093486
更新日期:2006-01-01 00:00:00
abstract::A total of 1,442 patients with symptoms of chronic prostatitis were examined over a 4-year period at the Outpatient Department for Urogenital Infections, University Hospital for Infectious Diseases Dr. Fran Mihaljević, Zagreb, Croatia. The inclusion criteria for chronic prostatitis caused by Ureaplasma urealyticum wer...
journal_title:Chemotherapy
pub_type: 杂志文章,随机对照试验
doi:10.1159/000090234
更新日期:2006-01-01 00:00:00